منابع مشابه
Beyond the GWAS in schizophrenia
The identification of the genetic factors that influence susceptibility to neuropsychiatric illness has proven challenging. Currently, several approaches are being utilized to enhance the potential of these studies. Most commonly, a ‘discovery’ genome wide association study (GWAS) with a focus on a single clinical diagnostic group such as schizophrenia, with subsequent replication in independen...
متن کامل[Systematic review of the Genomewide Association Studies (GWAS) in schizophrenia].
INTRODUCTION Heritability in schizophrenia can reach up to 80% and the risk in families is 5-10 times higher than in the general population. The large contribution of genetics in this disorder has led to a growing interest in its study. OBJECTIVES To review the findings of genetic studies known as Genomewide Association Studies (GWAS) on schizophrenia. METHOD Systematic search using Pubmed ...
متن کاملType 2 Diabetes Genetics: Beyond GWAS.
The global epidemic of type 2 diabetes mellitus (T2D) is one of the most challenging problems of the 21(st) century leading cause of and the fifth death worldwide. Substantial evidence suggests that T2D is a multifactorial disease with a strong genetic component. Recent genome-wide association studies (GWAS) have successfully identified and replicated nearly 75 susceptibility loci associated wi...
متن کاملGenetics of rheumatoid arthritis: GWAS and beyond
The study of complex genetics in autoimmune diseases has progressed at a tremendous pace over the last 4 years, as a direct result of the enormous gains made by genome wide association studies (GWAS). Novel genetic findings are continuously being reported alongside the rapid development of genetic technologies, sophisticated statistical analysis, and larger sample collections. It is now becomin...
متن کاملAllele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS.
Numerous recent studies have suggested that phenotypic effects of DNA sequence variants can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA modification (ASM). Using Affymetrix SNP microarrays, we performed a comprehensive search of ASM effects in human post-mortem brain and sperm samples (total n = 256) from individuals with major psychosis and control individuals...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2011
ISSN: 1757-4676,1757-4684
DOI: 10.1002/emmm.201100137